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Year Number of Results
1995 1
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1997 3
1998 4
1999 4
2000 10
2001 4
2002 4
2003 5
2004 4
2005 4
2006 5
2007 2
2008 1
2009 1
2010 2
2012 1
2013 1
2014 2
2015 3
2017 3
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2020 6
2021 3
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75 results

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Page 1
Decoding the role of macrophages in periodontitis and type 2 diabetes using single-cell RNA-sequencing.
Agrafioti P, Morin-Baxter J, Tanagala KKK, Dubey S, Sims P, Lalla E, Momen-Heravi F. Agrafioti P, et al. FASEB J. 2022 Feb;36(2):e22136. doi: 10.1096/fj.202101198R. FASEB J. 2022. PMID: 35032412 Free PMC article.
Our bioinformatic inferences indicated divergent expression profiles in macrophages driven by transcriptional regulators CIITA, RELA, RFX5, and RUNX2. Macrophages in periodontitis expressed both pro-inflammatory and anti-inflammatory markers and their polarization w …
Our bioinformatic inferences indicated divergent expression profiles in macrophages driven by transcriptional regulators CIITA, RELA, …
CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes.
Lochamy J, Rogers EM, Boss JM. Lochamy J, et al. Mol Immunol. 2007 Feb;44(5):837-47. doi: 10.1016/j.molimm.2006.04.004. Epub 2006 May 24. Mol Immunol. 2007. PMID: 16730065
These DNA-binding proteins serve as a scaffold for the transcriptional coactivator class II transactivator (CIITA). To determine how CREB interacts with RFX and CIITA, co-immunoprecipitations and reporter assays were performed using a variety of CREB mutants. These …
These DNA-binding proteins serve as a scaffold for the transcriptional coactivator class II transactivator (CIITA). To determine how …
The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes.
Kern I, Steimle V, Siegrist CA, Mach B. Kern I, et al. Int Immunol. 1995 Aug;7(8):1295-9. doi: 10.1093/intimm/7.8.1295. Int Immunol. 1995. PMID: 7495736
From the study of MHC class II regulatory mutants, it was found recently that two novel transactivators, CIITA and RFX5, are essential for the control of MHC class II gene expression. We report here that CIITA and RFX5, although operating at different …
From the study of MHC class II regulatory mutants, it was found recently that two novel transactivators, CIITA and RFX5, are e …
Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5.
Scholl T, Mahanta SK, Strominger JL. Scholl T, et al. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6330-4. doi: 10.1073/pnas.94.12.6330. Proc Natl Acad Sci U S A. 1997. PMID: 9177217 Free PMC article.
Finally, a direct interaction between RFX5 and CIITA was detected with the yeast two-hybrid and far-Western blot assays. Thus, RFX5 can activate transcription only in cooperation with CIITA. RFX5 and CIITA associate to form a complex capa …
Finally, a direct interaction between RFX5 and CIITA was detected with the yeast two-hybrid and far-Western blot assays. Thus, …
Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population.
Xue Y, Tang D, Li SJ, Zhou J, Hsueh CY, Zhao DD, Heng Y, Tao L, Lu LM. Xue Y, et al. Pathol Res Pract. 2020 Jan;216(1):152793. doi: 10.1016/j.prp.2019.152793. Epub 2019 Dec 18. Pathol Res Pract. 2020. PMID: 31870593
CIITA mutations have been previously associated with several kinds of tumors, while the role of CIITA polymorphisms (rs3087456) in laryngeal squamous cell carcinoma (LSCC) is little known. ...The relationship between the genotype of rs3087456 in controls and in clin …
CIITA mutations have been previously associated with several kinds of tumors, while the role of CIITA polymorphisms (rs3087456 …
In vivo, RFX5 binds differently to the human leucocyte antigen-E, -F, and -G gene promoters and participates in HLA class I protein expression in a cell type-dependent manner.
Rousseau P, Masternak K, Krawczyk M, Reith W, Dausset J, Carosella ED, Moreau P. Rousseau P, et al. Immunology. 2004 Jan;111(1):53-65. doi: 10.1111/j.1365-2567.2004.01783.x. Immunology. 2004. PMID: 14678199 Free PMC article.
Chromatin immunoprecipitation assays, performed on HLA-G positive and negative cell lines, demonstrated the in situ binding of RFX5 and CIITA to HLA-E and HLA-F, but not to HLA-G, promoters. In B cells from bare lymphocyte syndrome patients lacking RFX5 or …
Chromatin immunoprecipitation assays, performed on HLA-G positive and negative cell lines, demonstrated the in situ binding of RFX5 a …
HLA-DRB1 genes and the expression dynamics of HLA CIITA determine the susceptibility to T2DM.
Chinniah R, Sevak V, Pandi S, Ravi PM, Vijayan M, Kannan A, Karuppiah B. Chinniah R, et al. Immunogenetics. 2021 Aug;73(4):291-305. doi: 10.1007/s00251-021-01212-x. Epub 2021 Mar 22. Immunogenetics. 2021. PMID: 33754173
The expression of major histocompatibility complex class II genes are regulated by several trans-activators. We have studied the expression of HLA-DRB1, RFX, CIITA-P1, PIV transactivators, immunophenotyping of cells, SNPs in CIITA-168 (A/G) and IFN-gamma + 874 (T/A) …
The expression of major histocompatibility complex class II genes are regulated by several trans-activators. We have studied the expression …
Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression.
Xu Y, Farmer SR, Smith BD. Xu Y, et al. J Biol Chem. 2007 Sep 7;282(36):26046-56. doi: 10.1074/jbc.M703652200. Epub 2007 Jul 3. J Biol Chem. 2007. PMID: 17611194 Free article.
Previous studies indicate that IFN-gamma represses collagen gene expression and induces major histocompatibility complex II (MHC II) expression by activating the formation of a regulatory factor for X-box 5 (RFX5) complex with class II transactivator (CIITA). This r …
Previous studies indicate that IFN-gamma represses collagen gene expression and induces major histocompatibility complex II (MHC II) express …
Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.
Clausen BE, Waldburger JM, Schwenk F, Barras E, Mach B, Rajewsky K, Förster I, Reith W. Clausen BE, et al. Immunity. 1998 Feb;8(2):143-55. doi: 10.1016/s1074-7613(00)80467-7. Immunity. 1998. PMID: 9491996 Free article.
Patients with major histocompatibility complex class II (MHC-II) deficiency are known to carry mutations in either the RFX complex or the trans-activator CIITA. While the pivotal role of CIITA for MHC-II gene transcription is supported by the essential absence of MH …
Patients with major histocompatibility complex class II (MHC-II) deficiency are known to carry mutations in either the RFX complex or the tr …
Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.
Wong D, Lee W, Humburg P, Makino S, Lau E, Naranbhai V, Fairfax BP, Chan K, Plant K, Knight JC. Wong D, et al. Genome Biol. 2014;15(10):494. doi: 10.1186/s13059-014-0494-z. Genome Biol. 2014. PMID: 25366989 Free PMC article.
RESULTS: We report the first genome-wide ChIP-seq map for CIITA and complement this by mapping inter-individual variation in CIITA expression as a quantitative trait. ...We confirm recruitment to proximal promoter sequences in MHC class II genes and more distally in …
RESULTS: We report the first genome-wide ChIP-seq map for CIITA and complement this by mapping inter-individual variation in CIITA …
75 results